Instrumentation for Drug Binding Kinetics

The University of Gothenburg intend to purchase an instrument that will be used for measurements of binding kinetics of small-molecule ligands towards biological membranes and proteins. The department of Pharmacology is investigating drug distribution processes and the immediate focus is to quantify binding kinetics (on- and off-rates) and binding affinities of ligands towards immobilized cellular membranes. In this context we study series of tens-to-thousands of small-molecule ligands, and a setup is necessary in which crude cell homogenates or similar cell membrane preparations are immobilized on the sensor surface, and sets of multiple ligands are screened through addition as solutions in aqueous buffer, typically supplemented with dimethyl sulfoxide (DMSO).

Avsnitt nummer: IV.2.2)

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Avsnitt nummer: IV.2.6)

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Avsnitt nummer: IV.2.7)

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