Services - 250088-2021

19/05/2021    S96

Italy-Parma: Investigating in Vitro Tools for the Toxicological Evaluation of Proteins in Food and Feed Risk Assessment

2021/S 096-250088

Prior information notice

This notice is for prior information only

Services

Legal Basis:
Regulation (EU, Euratom) No 2018/1046

Section I: Contracting authority

I.1)Name and addresses
Official name: European Food Safety Authority (EFSA)
Postal address: Via Carlo Magno 1A
Town: Parma
NUTS code: ITH52 Parma
Postal code: 43126
Country: Italy
E-mail: EFSAProcurement@efsa.europa.eu
Internet address(es):
Main address: http://www.efsa.europa.eu/en/procurement/tenders
Address of the buyer profile: http://www.efsa.europa.eu/en/procurement/tenders
I.3)Communication
Additional information can be obtained from the abovementioned address
I.4)Type of the contracting authority
European institution/agency or international organisation
I.5)Main activity
General public services

Section II: Object

II.1)Scope of the procurement
II.1.1)Title:

Investigating in Vitro Tools for the Toxicological Evaluation of Proteins in Food and Feed Risk Assessment

Reference number: OC/EFSA/GMO/2021/03
II.1.2)Main CPV code
73200000 Research and development consultancy services
II.1.3)Type of contract
Services
II.1.4)Short description:

Protein toxicity can be due to various mechanisms of action at molecular level (e.g. ion channel inhibitor activity, metal ion binding, etc), or be associated to biological processes (e.g. hemolysis, lipid catabolic process, defence response) and/or on the basis of the cellular component affected (Palazzolo et al. 2020). Proteins under assessment can be tested using in vitro systems, this efficiently integrating in silico predictions. The target of this work is to gather information on the available in vitro systems used to test the above toxicity mechanisms, processes or relevant cellular components and to evaluate their applicability to testing protein toxicity. Following the identification of in vitro tools, testing strategies for selected toxic proteins (i.e. identification of fit-for purpose battery of in vitro tools for a selection of toxic proteins) should also be developed.

II.1.5)Estimated total value
Value excluding VAT: 150 000.00 EUR
II.1.6)Information about lots
This contract is divided into lots: no
II.2)Description
II.2.3)Place of performance
NUTS code: ITH52 Parma
II.2.4)Description of the procurement:

Protein toxicity can be due to various mechanisms of action at molecular level (e.g. ion channel inhibitor activity, metal ion binding, etc), or be associated to biological processes (e.g. hemolysis, lipid catabolic process, defence response) and/or on the basis of the cellular component affected (Palazzolo et al. 2020). Proteins under assessment can be tested using in vitro systems, this efficiently integrating in silico predictions. The target of this work is to gather information on the available in vitro systems used to test the above toxicity mechanisms, processes or relevant cellular components and to evaluate their applicability to testing protein toxicity. Following the identification of in vitro tools, testing strategies for selected toxic proteins (i.e. identification of fit-for purpose battery of in vitro tools for a selection of toxic proteins) should also be developed.

II.2.14)Additional information
II.3)Estimated date of publication of contract notice:
30/06/2021

Section IV: Procedure

IV.1)Description
IV.1.8)Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: no

Section VI: Complementary information

VI.3)Additional information:
VI.5)Date of dispatch of this notice:
12/05/2021