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Services - 14255-2022

11/01/2022    S7

Germany-Berlin: Research laboratory services

2022/S 007-014255

Contract award notice

Results of the procurement procedure

Services

Legal Basis:
Directive 2014/24/EU

Section I: Contracting authority

I.1)Name and addresses
Official name: EU-OPENSCREEN ERIC
Postal address: Robert-Rössle-Str. 10
Town: Berlin
NUTS code: DE3 Berlin
Postal code: 13125
Country: Germany
E-mail: wolfgang.fecke@eu-openscreen.eu
Internet address(es):
Main address: www.eu-openscreen.eu
I.4)Type of the contracting authority
European institution/agency or international organisation
I.5)Main activity
Other activity: Research

Section II: Object

II.1)Scope of the procurement
II.1.1)Title:

Bioprofiling Assays

II.1.2)Main CPV code
73111000 Research laboratory services
II.1.3)Type of contract
Services
II.1.4)Short description:

All compounds in the EU-OPENSCREEN compound collection will be characterised for a basic set of properties which are relevant for chemical biology or drug discovery projects. Compounds entering the EU-OPENSCREEN compound collection will be carefully characterised and annotated for basic physicochemical (e.g. solubility, compund aggregation) and biological properties (e.g. cell viability, anti-microbial activity) by testing them in a standard panel termed ‘bioprofiling’ assays´.

Bioprofiling of the EU-OPENSCREEN compound collection in a standardised manner will contribute to the wealth of quantitative data on compound bioactivities and will comprehensively characterise each of the compounds before they are utilised by the scientific community. Bioprofiling services will be provided at one or more partner sites in the EU OPENSCREEN ERIC network.

II.1.6)Information about lots
This contract is divided into lots: yes
II.1.7)Total value of the procurement (excluding VAT)
Value excluding VAT: 1.00 EUR
II.2)Description
II.2.1)Title:

Aggregation Physicochemical

Lot No: 1
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 1:

The formation of soluble compound aggregates is a major cause of false positives and distorted values in HTS assays.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Solubility Physicochemical

Lot No: 2
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 2:

Poor solubility can mask compound activity in bioassays inkluding underestimated activity, reduced hit rates in HTS and variable data outputs.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Determination of pKa Physicochemical

Lot No: 3
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 3:

The ionisation value of a compound reflects the diffusion rate across membranes and influences lipophilicity, solubility and protein binding, and therefore is an important parameter for compound optimization.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Determination of logP (partition coefficient) and logD (distribution coefficient) Physicochemical

Lot No: 4
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 4:

These parameters describe the lipophilicity of neutral (logP) and ionizable compounds (logD) and are therefore important values for predicting their behaviour (solubility, permeability) at physiological environments and different pH.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Interference with common Bioluminescence reporters Biochemical

Lot No: 5
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 5:

Important readout for many cellular reporter format assays. Will identify potential screening artefacts/false positives based on modulation of reporter enzymes.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

ROS (Reactive Oxygen Species) Biochemical

Lot No: 6
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 6:

Redox active compounds are commonly found in many screens as false positives as they can oxidize disulfide bridges in proteins or react with important co-factors.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Cell viability Cell-based

Lot No: 7
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 7:

Detection of the number of living cells by various means, e.g. measurement of ATP.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Antibacterial and antifungal assays Biological

Lot No: 8
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 8:

Deliver information about potential antibacterial and antifungal properies by testing compounds in a panel of growth assays.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:

Cell-painting Cell-based

Lot No: 9
II.2.2)Additional CPV code(s)
73111000 Research laboratory services
II.2.3)Place of performance
NUTS code: DE3 Berlin
Main site or place of performance:

Berlin

II.2.4)Description of the procurement:

Assay 9:

Multiplexes many readouts based on the use of several fluorescent dyes to reveal broadly relevant changes of cellular pomponents or organelles.

II.2.5)Award criteria
Quality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about options
Options: no
II.2.13)Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information

Section IV: Procedure

IV.1)Description
IV.1.1)Type of procedure
Award of a contract without prior publication of a call for competition in the Official Journal of the European Union in the cases listed below
  • The procurement falls outside the scope of application of the directive
Explanation:

According to the Statutes and Internal Rules of EU-OPENSCREEN ERIC bioprofiling shall be provided by one or more partner sites. EU-OPENSCREEN partner sites are entities with scientific and technological capabilities approved by a specific procedure according to the Statutes of EU-OPENSCREEN ERIC. Cooperation between EU-OPENSCREEN ERIC and partner sites is not subject to open procurement procedures pursuant to § 108 VI GWB. EU-OPENSCREEN bioprofiling services will be provided at one or more partner sites in the EU-OPENSCREEN network (https://www.eu-openscreen.eu/services/partner-sites.html).

IV.1.3)Information about a framework agreement or a dynamic purchasing system
IV.1.8)Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: yes
IV.2)Administrative information
IV.2.1)Previous publication concerning this procedure
Notice number in the OJ S: 2021/S 056-142277
IV.2.8)Information about termination of dynamic purchasing system
IV.2.9)Information about termination of call for competition in the form of a prior information notice

Section V: Award of contract

Lot No: Assay 1
Title:

Aggregation Physicochemical

A contract/lot is awarded: no
V.1)Information on non-award
The contract/lot is not awarded
No tenders or requests to participate were received or all were rejected

Section V: Award of contract

Lot No: Assay 2
Title:

Solubility Physicochemical

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/06/2021
V.2.2)Information about tenders
Number of tenders received: 1
The contract has been awarded to a group of economic operators: no
V.2.3)Name and address of the contractor
Official name: University of Santiago de Compostela
Town: Santiago de Compostela
NUTS code: ES111 A Coruña
Country: Spain
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting

Section V: Award of contract

Lot No: Assay 3
Title:

Determination of pKa Physicochemical

A contract/lot is awarded: no
V.1)Information on non-award
The contract/lot is not awarded
No tenders or requests to participate were received or all were rejected

Section V: Award of contract

Lot No: Assay 4
Title:

Determination of logP (partition coefficient) and logD (distribution coefficient) Physicochemical

A contract/lot is awarded: no
V.1)Information on non-award
The contract/lot is not awarded
No tenders or requests to participate were received or all were rejected

Section V: Award of contract

Lot No: Assay 5
Title:

Interference with common Bioluminescence reporters Biochemical

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/06/2021
V.2.2)Information about tenders
Number of tenders received: 1
The contract has been awarded to a group of economic operators: no
V.2.3)Name and address of the contractor
Official name: Polish Academy of Sciences, Institute of Bioorganic Chemistry (IBCH PAS)
Town: Warsaw
NUTS code: PL91 Warszawski stołeczny
Country: Poland
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting

Section V: Award of contract

Lot No: Assay 6
Title:

ROS (Reactive Oxygen Species)

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/06/2021
V.2.2)Information about tenders
Number of tenders received: 5
The contract has been awarded to a group of economic operators: no
V.2.3)Name and address of the contractor
Official name: Polish Academy of Sciences, Institute of Bioorganic Chemistry (IBCH PAS)
Town: Warsaw
NUTS code: PL91 Warszawski stołeczny
Country: Poland
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting

Section V: Award of contract

Lot No: Assay 7
Title:

Cell viability Cell-based

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/06/2021
V.2.2)Information about tenders
Number of tenders received: 5
The contract has been awarded to a group of economic operators: no
V.2.3)Name and address of the contractor
Official name: Institute for Molecular Medicine Finland (FIMM)
Town: Helsinki
NUTS code: FI1B Helsinki-Uusimaa
Country: Finland
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting

Section V: Award of contract

Lot No: Assay 8
Title:

Antibacterial and antifungal assays Biological

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/06/2021
V.2.2)Information about tenders
Number of tenders received: 2
The contract has been awarded to a group of economic operators: no
V.2.3)Name and address of the contractor
Official name: Fundación MEDINA (MEDI)
Town: Granada
NUTS code: ES614 Granada
Country: Spain
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting
The contract is likely to be subcontracted
Value or proportion likely to be subcontracted to third parties
Proportion: 44 %
Short description of the part of the contract to be subcontracted:

subcontracts were awarded to Helmholtz Centre for Infection Research (HZI)

Section V: Award of contract

Lot No: Assay 9
Title:

Cell-painting Cell-based

A contract/lot is awarded: yes
V.2)Award of contract
V.2.1)Date of conclusion of the contract:
29/09/2021
V.2.2)Information about tenders
Number of tenders received: 6
The contract has been awarded to a group of economic operators: yes
V.2.3)Name and address of the contractor
Official name: Fundación MEDINA (MEDI)
Town: Granada
NUTS code: ES614 Granada
Country: Spain
The contractor is an SME: no
V.2.3)Name and address of the contractor
Official name: University of Santiago Compostela (USC)
Town: Santiago Compostela
NUTS code: ES111 A Coruña
Country: Spain
The contractor is an SME: no
V.2.3)Name and address of the contractor
Official name: Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)
Town: Berlin
NUTS code: DE3 Berlin
Country: Germany
The contractor is an SME: no
V.2.3)Name and address of the contractor
Official name: Institute of Molecular and Translational Medicine, Palacky University Olomouc (IMTM)
Town: Olomouc
NUTS code: CZ071 Olomoucký kraj
Country: Czechia
The contractor is an SME: no
V.2.4)Information on value of the contract/lot (excluding VAT)
Total value of the contract/lot: 1.00 EUR
V.2.5)Information about subcontracting

Section VI: Complementary information

VI.3)Additional information:

According to the Statutes and Internal Rules of EU-OPENSCREEN ERIC bioprofiling shall be provided by one or more partner sites. EU-OPENSCREEN Partner Sites are entities with scientific and technological capabilities approved by a specific procedure according to the Statutes of EU-OPENSCREEN ERIC. Cooperation between EU-OPENSCREEN ERIC and partner sites is not subject to open procurement procedures pursuant to § 108 VI GWB. EU-OPENSCREEN bioprofiling services will be provided at one or more partner sites in the EU-OPENSCREEN network (https://www.eu-openscreen.eu/services/partner-sites.html). This notice is used as a means of transparency not as an open call for competition. EU-OPENSCREEN ERIC bioprofiling call was launched in February 2021. It is adressed to Partner Sites of EU-OPENSCREEN ERIC only. Procurement of the assay services follows the principles of transparency, non-discrimination, equal opportunity and competition. (Data shown under II.1.7 and V.2.4 do not contain information about the results of the call for competition. Entries had to be made due to the enotices form. Note to V.2.3: We have no information if the contractors are SME. Note to V.2.5 (Assay 9): The contract was awarded to four contractors.) Financing of the bioprofiling assays is funded by grants of the German Federal Ministry of Education and Research.

VI.4)Procedures for review
VI.4.1)Review body
Official name: Vergabekammer des Landes Berlin
Postal address: Martin-Luther-Str. 105
Town: Berlin
Postal code: 10825
Country: Germany
Telephone: +49 3090138316
Fax: +49 3090137613
VI.4.3)Review procedure
Precise information on deadline(s) for review procedures:

EU Openscreen ERIC is an international organisation according to art. 9 Abs. 1b RL 2014/24/EU, § 109 GWB.

VI.5)Date of dispatch of this notice:
06/01/2022