Section II: Object
II.1)Scope of the procurement
II.1.2)Main CPV code73111000 Research laboratory services
II.1.3)Type of contractServices
II.1.4)Short description:
All compounds in the EU-OPENSCREEN compound collection will be characterised for a basic set of properties which are relevant for chemical biology or drug discovery projects. Compounds entering the EU-OPENSCREEN compound collection will be carefully characterised and annotated for basic physicochemical (e.g. solubility, compund aggregation) and biological properties (e.g. cell viability, anti-microbial activity) by testing them in a standard panel termed ‘bioprofiling’ assays´.
Bioprofiling of the EU-OPENSCREEN compound collection in a standardised manner will contribute to the wealth of quantitative data on compound bioactivities and will comprehensively characterise each of the compounds before they are utilised by the scientific community. Bioprofiling services will be provided at one or more partner sites in the EU OPENSCREEN ERIC network.
II.1.6)Information about lotsThis contract is divided into lots: yes
II.1.7)Total value of the procurement (excluding VAT)Value excluding VAT: 1.00 EUR
II.2)Description
II.2.1)Title:
Aggregation Physicochemical
Lot No: 1
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 1:
The formation of soluble compound aggregates is a major cause of false positives and distorted values in HTS assays.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Solubility Physicochemical
Lot No: 2
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 2:
Poor solubility can mask compound activity in bioassays inkluding underestimated activity, reduced hit rates in HTS and variable data outputs.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Determination of pKa Physicochemical
Lot No: 3
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 3:
The ionisation value of a compound reflects the diffusion rate across membranes and influences lipophilicity, solubility and protein binding, and therefore is an important parameter for compound optimization.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Determination of logP (partition coefficient) and logD (distribution coefficient) Physicochemical
Lot No: 4
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 4:
These parameters describe the lipophilicity of neutral (logP) and ionizable compounds (logD) and are therefore important values for predicting their behaviour (solubility, permeability) at physiological environments and different pH.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Interference with common Bioluminescence reporters Biochemical
Lot No: 5
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 5:
Important readout for many cellular reporter format assays. Will identify potential screening artefacts/false positives based on modulation of reporter enzymes.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
ROS (Reactive Oxygen Species) Biochemical
Lot No: 6
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 6:
Redox active compounds are commonly found in many screens as false positives as they can oxidize disulfide bridges in proteins or react with important co-factors.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Cell viability Cell-based
Lot No: 7
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 7:
Detection of the number of living cells by various means, e.g. measurement of ATP.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.1)Title:
Antibacterial and antifungal assays Biological
Lot No: 8
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 8:
Deliver information about potential antibacterial and antifungal properies by testing compounds in a panel of growth assays.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information
II.2)Description
II.2.2)Additional CPV code(s)73111000 Research laboratory services
II.2.3)Place of performanceNUTS code: DE3 Berlin
Main site or place of performance:
II.2.4)Description of the procurement:
Assay 9:
Multiplexes many readouts based on the use of several fluorescent dyes to reveal broadly relevant changes of cellular pomponents or organelles.
II.2.5)Award criteriaQuality criterion - Name: Adequate description and clarity of the assay. / Weighting: 20 %
Quality criterion - Name: Assay validation experiments / Assay performance and sensitivity / Availability of assay validation data for assays. / Weighting: 30 %
Quality criterion - Name: Proven track record of the services provider, excellence of the provider. / Weighting: 5 %
Quality criterion - Name: Consumption of tested compounds. / Weighting: 5 %
Cost criterion - Name: Assay cost and timelines. / Weighting: 40 %
II.2.11)Information about optionsOptions: no
II.2.13)Information about European Union fundsThe procurement is related to a project and/or programme financed by European Union funds: no
II.2.14)Additional information