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Italy-Parma: Implementation of a Multi-OMICs and Inter-species Workflow to Derive Human Reference Points and Health-based Guidance Values (HBGVs) from Quantitative in Vitro Data
Section I: Contracting authority
Section II: Object
Implementation of a Multi-OMICs and Inter-species Workflow to Derive Human Reference Points and Health-based Guidance Values (HBGVs) from Quantitative in Vitro Data
The overarching goal of the project is to define, validate and apply a standardised workflow (experimental and computational) for deriving reliable human reference points and HBGVs using cutting edge in-vitro approaches, namely organ-on-a-chip (OoC) platforms and multiple OMICs endpoints (transcriptomics, metabolomics, epigenomics).
Implementation of a Multi-OMICs and Inter-species Workflow (Objective 1)
• Objective 1: Implementation of a multi-OMICs and inter-species workflow. In phase one, a set of data-rich substances will be selected (6 to 12 compounds) and used for an extensive toxicological screening based on OoC and multi-OMICs profiling (transcriptomics, epigenomics, metabolomics). Selected substances will include legacy hazards in food/feed and compounds/nutrients with positive health claims (e.g. resveratrol, to be used to verify applicability of OMICs in assessing beneficial dietary effects). The experimental design will be largely based on the procedures established in EU ToxRisk.
Lot 2 – Inference of Chemical Grouping from Processed OMICS Data in CTD (Objective 2)
• Objective 2: Inference of chemical grouping from processed OMICS data in the comparative toxicogenomics database (CTD).
Section III: Legal, economic, financial and technical information
As stated in the procurement documents.
Section IV: Procedure
Section VI: Complementary information
‘In case of unavailability or disruptions in the functioning of the electronic means of communication provided in Section I.3) in the last five calendar days before the time limit for receipt indicated in Section IV.2.2), the contracting authority reserves the right to extend this time limit and publish the extension at the internet address provided in Section I.3), without a preceding publication of a corrigendum to this notice. Economic operators interested in this procurement are invited to subscribe to the call for tenders at the address in Section I.3) in order to get notified when new information or documents are published.’